In Diablo 4, progressing through World Tiers not only increases difficulty but significantly enhances the quality and quantity of loot. However, optimizing farming in higher tiers like World Tier III and IV requires specific strategies to avoid unnecessary deaths and resource waste. Understanding enemy scaling, elemental resistances, and affix management is crucial at these levels.

Players should prioritize building their character around survivability and AoE damage. In World Tier IV, the number of elite packs increases drastically, and each fight can become deadly without optimized gear. Crowd control resistance and defensive affixes like Damage Reduction from Close Enemies can dramatically boost your survivability.

Nightmare Dungeons become the central farming content at higher World Tiers. Choose dungeons that align with your build’s strengths—for example, ranged builds benefit more from open layouts like Mariner’s Refuge, while melee classes prefer tighter corridors like Hoarfrost Demise.

Efficient sigil crafting is vital. Avoid wasting materials on high-difficulty sigils for dungeons with terrible layouts or unfavorable affixes. Instead, recycle or salvage unwanted sigils to get better rolls that match your farming style. Learn to read affixes carefully—avoid modifiers like "Resource Burn" or "Cold Enchanted" if they cripple your playstyle.

Helltides remain one of the best sources for Forgotten Souls and Fiend Roses. Time your farming runs with a group if possible, and avoid engaging in PvP zones unless you’re confident in your gear and reflexes. Use mounts and waypoints wisely to rotate between chest zones.

One overlooked tip is to prepare in advance by farming Whisper Caches. These offer targeted loot and save significant time in item-hunting at higher tiers. Always choose reward types aligned with your build, like Two-Handed Weapons for Barbarians or Focuses for Sorcerers.

Lastly, group synergy greatly improves farming speed. Coordinate with friends or join communities for regular World Tier runs. Not only is farming safer with allies, but elite clearing and boss killing becomes significantly faster, increasing your overall efficiency per hour.
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